Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B (ANP32B) Antibody

Background

ANP32B is a nuclear phosphoprotein that shares structural and functional similarities with ANP32A, particularly in chromatin regulation and RNA processing. ANP32B functions as a regulator of apoptosis, cell proliferation, and gene transcription, making it critical for cellular homeostasis and growth control. It is essential for embryonic development, with knockout studies indicating its requirement for cell survival and proper organogenesis. ANP32B also modulates the activity of HDAC complexes, contributing to histone deacetylation and transcriptional repression. Dysregulation of ANP32B has been linked to cancer progression and metastasis, where it promotes cell proliferation and resistance to apoptosis. Its involvement in multiple pathways underscores its importance as a potential therapeutic target in oncology.