ANKRD6 antibody
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935106861
info@markelab.com
name
ANKRD6 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00420
tested applications
ELISA, IP, WB, IHC
Description
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ankyrin repeat domain 6 (ANKRD6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 80 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IP, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y2G4 |
| Gene ID | 22881 |
| Alias | ANKRD6,KIAA0957 |
| Background | Antibody anti-ANKRD6 |
| Status | RUO |
| Note | Mol. Weight 80 kDa |
Descripción
ANKRD6, also known as Diversity And Specificity Armadillo (DIVERSIN), is a critical regulator of the Wnt signaling pathway, which controls cell fate, proliferation, and differentiation during embryonic development and tissue homeostasis. ANKRD6 interacts with components of the β-catenin destruction complex to regulate the degradation of β-catenin, a key effector of canonical Wnt signaling. In addition, ANKRD6 modulates the non-canonical Wnt pathway, influencing processes like cell polarity and migration. ANKRD6 is essential for developmental processes, including organ formation and stem cell regulation, and its dysregulation has been linked to cancer progression and developmental disorders. Its role as a Wnt pathway regulator highlights its importance in maintaining proper signaling and cellular organization.
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