anti- ANKRD13D antibody
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935106861
info@markelab.com
Precio
Precio a consultar
Antibody anti-ANKRD13D
proveedor
FineTestreference
FNab00409Tested Applications
ELISA, WB, IHCreactivity
humanstatus
RUOclonality
polyclonalDescripción
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Background
ANKRD13D is another member of the ANKRD13 family that contains ankyrin repeats and is involved in protein trafficking and ubiquitination. Similar to other ANKRD13 family members, ANKRD13D regulates the stability, localization, and degradation of membrane and cytosolic proteins. It interacts with ubiquitin-binding domains and components of the endosomal system, participating in the selective sorting and recycling of proteins. ANKRD13D is thought to play a role in cellular signaling pathways by modulating the availability and activity of receptors and signaling proteins. Dysregulation of ANKRD13D has been associated with cellular dysfunction, contributing to the development of cancers and disorders involving disrupted proteostasis. Its function in protein quality control and trafficking highlights its significance in regulating cellular signaling and homeostasis.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human
immunogen target
ankyrin repeat domain 13 family, member D
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IHC
observerd MW
58 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:200-1:1000; IHC: 1:20-1:200
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
ANKRD13D
alias
ANKRD13D
uniprot id
note
This product is for research use only.
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