ANKRD13D antibody
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935106861
info@markelab.com
name
ANKRD13D antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00409
tested applications
ELISA, WB, IHC
Description
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ankyrin repeat domain 13 family, member D (ANKRD13D) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 58 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6ZTN6 |
| Gene ID | 338692 |
| Alias | ANKRD13D |
| Background | Antibody anti-ANKRD13D |
| Status | RUO |
| Note | Mol. Weight 58 kDa |
Descripción
ANKRD13D is another member of the ANKRD13 family that contains ankyrin repeats and is involved in protein trafficking and ubiquitination. Similar to other ANKRD13 family members, ANKRD13D regulates the stability, localization, and degradation of membrane and cytosolic proteins. It interacts with ubiquitin-binding domains and components of the endosomal system, participating in the selective sorting and recycling of proteins. ANKRD13D is thought to play a role in cellular signaling pathways by modulating the availability and activity of receptors and signaling proteins. Dysregulation of ANKRD13D has been associated with cellular dysfunction, contributing to the development of cancers and disorders involving disrupted proteostasis. Its function in protein quality control and trafficking highlights its significance in regulating cellular signaling and homeostasis.
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