ANKRD13B antibody
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935106861
info@markelab.com
name
ANKRD13B antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00407
tested applications
ELISA, WB, IHC
Description
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ankyrin repeat domain 13B (ANKRD13B) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86YJ7 |
| Gene ID | 124930 |
| Alias | ANKRD13B |
| Background | Antibody anti-ANKRD13B |
| Status | RUO |
| Note | Mol. Weight 70 kDa |
Descripción
ANKRD13B is closely related to ANKRD13A and shares similar functions involving protein trafficking and ubiquitination. It contains ankyrin repeat domains that facilitate the interaction with other proteins and regulate their localization and stability. ANKRD13B is implicated in the endocytic pathway, where it modulates the internalization and degradation of plasma membrane proteins, including signaling receptors. It is also thought to play a role in sorting proteins for lysosomal degradation. Disruption of ANKRD13B function may impair protein turnover, contributing to cellular stress and disease progression. Studies suggest that ANKRD13B may be involved in pathways relevant to tumorigenesis and cellular signaling, where altered protein recycling can affect growth factor receptor activity and downstream signaling cascades.
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