Ankyrin Repeat Domain 13B (ANKRD13B) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Ankyrin Repeat Domain 13B (ANKRD13B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230407
tested applications
ELISA, WB, IHC
Description
ANKRD13B Antibody is a Rabbit Polyclonal against ANKRD13B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ankyrin Repeat Domain 13B (ANKRD13B) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86YJ7 |
| Gene ID | 124930 |
| OMIM | 615124 |
| Alias | ANKRD13B |
| Background | Antibody anti-ANKRD13B |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ANKRD13B is closely related to ANKRD13A and shares similar functions involving protein trafficking and ubiquitination. It contains ankyrin repeat domains that facilitate the interaction with other proteins and regulate their localization and stability. ANKRD13B is implicated in the endocytic pathway, where it modulates the internalization and degradation of plasma membrane proteins, including signaling receptors. It is also thought to play a role in sorting proteins for lysosomal degradation. Disruption of ANKRD13B function may impair protein turnover, contributing to cellular stress and disease progression. Studies suggest that ANKRD13B may be involved in pathways relevant to tumorigenesis and cellular signaling, where altered protein recycling can affect growth factor receptor activity and downstream signaling cascades.
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