ANGPTL8 antibody

Este producto es parte de ANGPTL - Angiopoietin Like
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935106861
info@markelab.com
name
ANGPTL8 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09883
tested applications
ELISA, WB, IHC

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Betatrophin (ANGPTL8)
Host
Rabbit
Reactivity
human, mouse
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
22 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q6UXH0
Gene ID
55908
Alias
PRO1185,PVPA599,RIFL
Background
Antibody anti-ANGPTL8
Status
RUO
Note
Mol. Weight 22 kDa

ANGPTL8, also known as betatrophin, is a hepatokine and adipokine involved in lipid metabolism, glucose homeostasis, and energy regulation. ANGPTL8 functions as a regulator of lipoprotein lipase (LPL) activity, working in coordination with ANGPTL3 to inhibit triglyceride hydrolysis and regulate circulating triglyceride levels. It is primarily expressed in the liver and adipose tissue, where its expression is upregulated in response to feeding and insulin signaling, linking it to nutrient status and energy balance. ANGPTL8 has also been implicated in beta-cell proliferation in the pancreas, where it was initially identified for its potential role in promoting insulin secretion and enhancing pancreatic beta-cell expansion. Dysregulation of ANGPTL8 is associated with obesity, metabolic syndrome, and type 2 diabetes, where altered lipid and glucose metabolism contribute to disease progression. ANGPTL8’s role as a modulator of lipid metabolism and glucose homeostasis makes it a promising target for the treatment of metabolic disorders, including hypertriglyceridemia and insulin resistance.

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