ANGPTL7 antibody

Este producto es parte de ANGPTL - Angiopoietin Like
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935106861
info@markelab.com
name
ANGPTL7 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00401
tested applications
ELISA, WB

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
angiopoietin-like 7 (ANGPTL7)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:200-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
45 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
O43827
Gene ID
10218
Alias
AngX,CDT6
Background
Antibody anti-ANGPTL7
Status
RUO
Note
Mol. Weight 45 kDa

ANGPTL7 is a secreted glycoprotein and a member of the angiopoietin-like (ANGPTL) protein family that regulates extracellular matrix (ECM) remodeling, angiogenesis, and ocular physiology. ANGPTL7 is highly expressed in the cornea and aqueous humor, where it plays a critical role in maintaining intraocular pressure and corneal transparency by modulating ECM composition and fluid outflow. Elevated levels of ANGPTL7 have been linked to primary open-angle glaucoma (POAG), a condition characterized by increased intraocular pressure and optic nerve damage. ANGPTL7 is also involved in tissue homeostasis and fibrosis through its regulation of collagen deposition and matrix degradation. Beyond its ocular functions, ANGPTL7 expression is upregulated under inflammatory conditions, suggesting a role in immune modulation and wound healing. Dysregulation of ANGPTL7 has been observed in certain cancers, where it may contribute to tumor progression by remodeling the tumor microenvironment. Its importance in ocular health and ECM regulation highlights ANGPTL7 as a potential therapeutic target for glaucoma and fibrotic diseases.

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