Angiopoietin-Related Protein 7 (ANGPTL7) Antibody

Este producto es parte de ANGPTL - Angiopoietin Like
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Angiopoietin-Related Protein 7 (ANGPTL7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026933
tested applications
ELISA, WB, IHC, FCM

Description

The function of this protein remains unknown.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Angiopoietin-Related Protein 7 (ANGPTL7)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified Rabbit Polyclonal Antibody.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC, FCM
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O43827
Alias
AngX,CDT6
Background
Antibody anti-ANGPTL7
Status
RUO

Descripción

ANGPTL7 is a secreted glycoprotein and a member of the angiopoietin-like (ANGPTL) protein family that regulates extracellular matrix (ECM) remodeling, angiogenesis, and ocular physiology. ANGPTL7 is highly expressed in the cornea and aqueous humor, where it plays a critical role in maintaining intraocular pressure and corneal transparency by modulating ECM composition and fluid outflow. Elevated levels of ANGPTL7 have been linked to primary open-angle glaucoma (POAG), a condition characterized by increased intraocular pressure and optic nerve damage. ANGPTL7 is also involved in tissue homeostasis and fibrosis through its regulation of collagen deposition and matrix degradation. Beyond its ocular functions, ANGPTL7 expression is upregulated under inflammatory conditions, suggesting a role in immune modulation and wound healing. Dysregulation of ANGPTL7 has been observed in certain cancers, where it may contribute to tumor progression by remodeling the tumor microenvironment. Its importance in ocular health and ECM regulation highlights ANGPTL7 as a potential therapeutic target for glaucoma and fibrotic diseases.

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