AMZ1 antibody
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935106861
info@markelab.com
name
AMZ1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00385
tested applications
ELISA, WB, IF, IHC
Description
AMZ1, also named as KIAA1950, is a new human Zinc metalloproteases. It exhibits aminopeptidase activity against neurogranin in vitro. AMZ1 does not hydrolyze angiotensin-2. It is mainly detected in liver and heart. AMZ1 has some isoforms with MW 55 kDa, 33 kDa, 30 kDa and 28 kDa.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | archaelysin family metallopeptidase 1 (AMZ1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 28 kDa, 33 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q400G9 |
| Gene ID | 155185 |
| Alias | AMZ1 |
| Background | Antibody anti-AMZ1 |
| Status | RUO |
| Note | Mol. Weight 28 kDa, 33 kDa |
Descripción
AMZ1 is a member of the archaelysin family of zinc-dependent metallopeptidases, enzymes that cleave peptide bonds in a variety of substrates. AMZ1 is expressed in multiple tissues, where it functions in protein turnover, extracellular matrix remodeling, and cellular signaling. As a metallopeptidase, AMZ1 requires a zinc ion for catalytic activity, which stabilizes the enzyme's active site and facilitates hydrolysis of peptide bonds. AMZ1 is thought to participate in processes such as tissue development, wound healing, and immune responses by regulating extracellular matrix components and growth factors. Dysregulation of AMZ1 activity has been implicated in pathological processes such as fibrosis, inflammation, and tumor progression, where excessive matrix degradation or improper protease activity contributes to disease. AMZ1's ability to cleave a broad range of substrates highlights its importance in maintaining proteolytic balance, tissue homeostasis, and intercellular communication.
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AMZ1 antibody
AMZ1, also named as KIAA1950, is a new human Zinc metalloproteases. It exhibits aminopeptidase activity against neurogranin in vitro. AMZ1 does not hydrolyze angiotensin-2. It is mainly detected in liver and heart. AMZ1 has some isoforms with MW 55 kDa, 33 kDa, 30 kDa and 28 kDa.
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