AMPD3 antibody
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Description
AMP deaminase plays a critical role in energy metabolism.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adenosine monophosphate deaminase(isoform E) (AMPD3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70-90 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q01432 |
| Gene ID | 272 |
| Alias | AMP deaminase isoform E |
| Background | Antibody anti-AMPD3 |
| Status | RUO |
| Note | Mol. Weight 70-90 kDa |
Descripción
AMPD3 is an isoform of AMP deaminase predominantly expressed in erythrocytes (red blood cells), where it catalyzes the conversion of AMP to IMP to regulate ATP and nucleotide levels under energy stress. AMPD3 activity is essential for maintaining erythrocyte energy homeostasis, as it helps sustain ATP levels and prevents the depletion of adenine nucleotides during cellular stress. Mutations in the AMPD3 gene lead to erythrocyte AMP deaminase deficiency, a condition characterized by reduced IMP production and altered ATP metabolism, although most affected individuals remain asymptomatic. AMPD3 has been implicated in hemolytic anemias and other red blood cell disorders where impaired energy metabolism compromises erythrocyte survival and function. Beyond its role in erythrocyte physiology, AMPD3 contributes to systemic purine metabolism and may influence energy balance in other tissues. Its importance in regulating erythrocyte energy levels highlights its critical role in red blood cell longevity and overall cellular energy balance.
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Recombinant Human AMPD3
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AMP Deaminase 3 (AMPD3) Antibody
AMPD3 Antibody is a Rabbit Polyclonal antibody against AMPD3. This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
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