alpha Tubulin antibody

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935106861
info@markelab.com
name
alpha Tubulin antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00334
tested applications
ELISA, IHC, IF, WB

Description

Alpha 1a Tubulin is also known as Alpha-tubulin 3. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Alpha 1a Tubulin is expressed at a high level in fetal brain.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
tubulin, alpha 1a (alpha Tubulin)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:5000; IF: 1:10-1:100; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
50 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, IHC, IF, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q71U36
Gene ID
7846
Alias
Tubulin alpha-1A chain,Alpha-tubulin 3,Tubulin B-alpha-1,Tubulin alpha-3 chain,Detyrosinated tubulin alpha-1A chain,TUBA1A,TUBA3
Background
Antibody anti-TUBA1A
Status
RUO
Note
Mol. Weight 50 kDa

Descripción

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Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin.

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Alpha 1a Tubulin is also known as Alpha-tubulin 3. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Alpha 1a Tubulin is expressed at a high level in fetal brain.

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