ALDH6A1 antibody
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935106861
info@markelab.com
name
ALDH6A1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00298
tested applications
ELISA, WB, IHC
Description
Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldehyde dehydrogenase 6 family, member A1 (ALDH6A1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:2000-1:10000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 58 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q02252 |
| Gene ID | 4329 |
| Alias | ALDH6A1, MMSADHA, MMSDH |
| Background | Antibody anti-ALDH6A1 |
| Status | RUO |
| Note | Mol. Weight 58 kDa |
Descripción
ALDH6A1, also known as methylmalonate semialdehyde dehydrogenase (MMSDH), is a mitochondrial enzyme involved in the catabolism of branched-chain amino acids (valine and thymine) and odd-chain fatty acids. It catalyzes the oxidation of methylmalonate semialdehyde to propionyl-CoA, which is further metabolized into succinyl-CoA, linking amino acid breakdown to the TCA cycle. ALDH6A1 plays a critical role in energy metabolism and maintaining metabolic flexibility during nutrient stress. Dysregulation of ALDH6A1 impairs amino acid and fatty acid metabolism, contributing to metabolic disorders, including methylmalonic aciduria and neurological deficits. Its activity is essential for detoxifying reactive intermediates formed during amino acid catabolism, protecting cells from oxidative stress. ALDH6A1 is particularly important in tissues with high metabolic demands, such as the liver, muscles, and brain.
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