ALDH3A2 antibody
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Description
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate(S1P) degradation product hexadecenal to hexadecenoic acid.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldehyde dehydrogenase 3 family, member A2 (ALDH3A2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100; IP: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P51648 |
| Gene ID | 224 |
| Alias | ALDH3A2,ALDH10,FALDH |
| Background | Antibody anti-ALDH3A2 |
| Status | RUO |
| Note | Mol. Weight 55 kDa |
Descripción
ALDH3A2, also known as fatty aldehyde dehydrogenase (FALDH), is a key enzyme that catalyzes the oxidation of fatty aldehydes to fatty acids. This process is essential for lipid metabolism, particularly in the breakdown of long-chain and very-long-chain fatty aldehydes derived from sphingolipids and dietary fats. Mutations in ALDH3A2 cause Sjögren-Larsson Syndrome (SLS), a rare autosomal recessive disorder characterized by ichthyosis (skin scaling), spasticity, and intellectual disability due to the accumulation of fatty aldehydes and disruption of lipid homeostasis. ALDH3A2 is expressed in the liver, brain, and skin, where it supports lipid metabolism and protects against oxidative stress. Its role in maintaining cellular membrane integrity and energy balance highlights its importance in metabolic and neuroprotective functions. Therapies targeting ALDH3A2 aim to restore fatty acid metabolism and alleviate symptoms of SLS, emphasizing its role in lipid-mediated pathologies.
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