anti- ALDH1B1 antibody
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935106861
info@markelab.com
name
anti- ALDH1B1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00287
tested applications
ELISA, WB, IHC, IP,IF
Description
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldehyde dehydrogenase 1 family, member B1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:3000; IHC: 1:20-1:200; IF: 1:20-1:200; IP: 1:500-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 56 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP,IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P30837 |
| Gene ID | 219 |
| Alias | ALDH1B1,ALDH5,ALDHX |
| Background | Antibody anti-ALDH1B1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ALDH1B1 is a mitochondrial enzyme that participates in the detoxification of aldehydes and the oxidation of acetaldehyde to acetate, a key step in ethanol metabolism. It is highly expressed in the liver, colon, and gastrointestinal tract, where it protects against oxidative stress and aldehyde-induced cellular damage. ALDH1B1 has been linked to alcohol metabolism, and its dysregulation contributes to alcohol-induced liver injury, cirrhosis, and colorectal cancer. In cancers, ALDH1B1 expression is often elevated, particularly in colorectal and pancreatic tumors, where it promotes tumorigenesis by maintaining cellular redox balance and enhancing proliferation. It also contributes to cancer stem-like properties, facilitating chemoresistance and tumor progression. Studies suggest ALDH1B1 as a promising biomarker and therapeutic target in gastrointestinal cancers and alcohol-associated diseases. Its role in mitochondrial aldehyde metabolism also links it to energy homeostasis and metabolic regulation.
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ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
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anti- ALDH1B1 antibody
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
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