AKT1 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
AKT1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab10227
Tested Applications
ELISA, WB, IHC
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | RAC-alpha serine/threonine-protein kinase (AKT1) |
| Host | Rabbit |
| Reactivity | Human, rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 48/55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P31749 |
| Gene ID | 207 |
| Alias | AKT1,PKB,RAC,RAC-ALPHA |
| Background | Antibody anti-AKT1 |
| Status | RUO |
| Note | Mol. Weight 48/55 kDa |
Background
The AKT (also known as Protein Kinase B) is a pivotal enzyme involved in regulating various cellular processes like metabolism, proliferation, survival, and growth. It acts downstream of phosphoinositide 3-kinase (PI3K) signaling pathway, which is activated by growth factors and cytokines. RAC-alpha serine/threonine-protein kinase is the full name of AKT. It belongs to the AGC (protein kinase A/protein kinase G/protein kinase C) family of kinases. AKT has three isoforms: AKT1, AKT2, and AKT3. Each isoform has slightly different tissue distributions and roles but shares the same basic structure and mechanism of action.Activation of AKT typically occurs through phosphorylation at two key residues: threonine 308 (Thr308) and serine 473 (Ser473). Once activated, AKT phosphorylates various downstream targets, including transcription factors, metabolic enzymes, and cell cycle regulators, ultimately leading to diverse cellular responses. Dysregulation of AKT signaling is implicated in various diseases, including cancer, diabetes, and cardiovascular diseases. Therefore, AKT has emerged as a significant target for therapeutic interventions in these conditions.
Productos relacionados
RAC-Alpha Serine/threonine-Protein Kinase Phospho-Thr450 (AKT1 pT450) Antibody
AKT1 (pT450) Antibody is a Rabbit Polyclonal antibody against AKT1 (pT450). The serine-threonine protein kinase encoded …
Ver producto
RAC-Alpha Serine/threonine-Protein Kinase Phospho-Ser473 (AKT1 pS473) Antibody
AKT1 (pS473) Antibody is a Rabbit Polyclonal antibody against AKT1 (pS473). The serine-threonine protein kinase encoded …
Ver producto
RAC-Alpha Serine/threonine-Protein Kinase Phospho-Ser473 (AKT1 pS473) Antibody
AKT1 (pS473) Antibody is a Rabbit Polyclonal antibody against AKT1 (pS473). The serine-threonine protein kinase encoded …
Ver producto