AKR1E2 antibody
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Name
AKR1E2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00264
Tested Applications
ELISA, WB, IF
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | aldo-keto reductase family 1, member C-like 2 (AKR1E2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 37 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96JD6 |
| Gene ID | 83592 |
| Alias | AKR1E2,AKR1CL2,AKRDC1 |
| Background | Antibody anti-AKR1E2 |
| Status | RUO |
| Note | Mol. Weight 37 kDa |
Background
AKR1E2 is a less characterized member of the aldo-keto reductase superfamily but is known to catalyze the reduction of various aldehydes and ketones, contributing to cellular detoxification and redox balance. AKR1E2 has a broad substrate specificity, metabolizing reactive aldehydes such as those derived from lipid peroxidation (4-HNE) and environmental toxins. Its enzymatic activity protects cells from oxidative stress and damage caused by reactive carbonyl species (RCS), linking it to cellular defense mechanisms. While its tissue-specific expression and physiological roles are still being elucidated, AKR1E2 likely plays a role in liver and kidney detoxification processes. Emerging evidence suggests its involvement in redox regulation and energy metabolism under stress conditions. Dysregulation of AKR1E2 may contribute to oxidative stress-associated diseases, including neurodegeneration, cardiovascular disease, and cancer, where impaired detoxification exacerbates cellular damage. Further studies are needed to clarify its unique functions and therapeutic potential.
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