AGPAT3 antibody
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Description
Converts lysophosphatidic acid(LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA(PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase(LPIAT) activity, converts lysophosphatidylinositol(LPI) into phosphatidylinositol(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 1-acylglycerol-3-phosphate O-acyltransferase 3 (AGPAT3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 36-40 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NRZ7 |
| Gene ID | 56894 |
| Alias | 1-AGPAT 3,LPAAT-GAMMA1 |
| Background | Antibody anti-AGPAT3 |
| Status | RUO |
| Note | Mol. Weight 36-40 kDa |
Descripción
AGPAT3 is another member of the AGPAT family involved in the acylation of lysophosphatidic acid (LPA) to form phosphatidic acid (PA). Unlike AGPAT1 and AGPAT2, AGPAT3 has broader substrate specificity and is expressed in multiple tissues, including the liver, brain, and kidneys. It participates in the synthesis of various phospholipids, such as phosphatidylcholine and phosphatidylethanolamine, which are essential for membrane biogenesis and cell signaling. AGPAT3 also plays a role in lipid remodeling and vesicle trafficking. Dysregulation of AGPAT3 has been associated with metabolic disorders, and emerging research suggests its potential involvement in neurological diseases and cancer due to its impact on membrane composition and signaling pathways.
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