anti- AGPAT3 antibody

Name: anti- AGPAT3 antibody
Brand: FineTest
SKU: FNab00216
Availability: OnlineOnly

Este producto es parte de AGPAT - 1-acyl-sn-glycerol-3-phosphate acyltransferase

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-AGPAT3

proveedor

FineTest

reference

FNab00216

Tested Applications

ELISA, WB

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

Converts lysophosphatidic acid(LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA(PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase(LPIAT) activity, converts lysophosphatidylinositol(LPI) into phosphatidylinositol(By similarity).

Background

AGPAT3 is another member of the AGPAT family involved in the acylation of lysophosphatidic acid (LPA) to form phosphatidic acid (PA). Unlike AGPAT1 and AGPAT2, AGPAT3 has broader substrate specificity and is expressed in multiple tissues, including the liver, brain, and kidneys. It participates in the synthesis of various phospholipids, such as phosphatidylcholine and phosphatidylethanolamine, which are essential for membrane biogenesis and cell signaling. AGPAT3 also plays a role in lipid remodeling and vesicle trafficking. Dysregulation of AGPAT3 has been associated with metabolic disorders, and emerging research suggests its potential involvement in neurological diseases and cancer due to its impact on membrane composition and signaling pathways.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

1-acylglycerol-3-phosphate O-acyltransferase 3

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB

observerd MW

36-40 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:500-1:5000

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

AGPAT3

alias

1-AGPAT 3,LPAAT-GAMMA1

uniprot id

https://www.uniprot.org/uniprotkb/Q9NRZ7

gene id

https://www.ncbi.nlm.nih.gov/gene/56894

note

This product is for research use only.

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