anti- AFF4 antibody

Name: anti- AFF4 antibody
Brand: FineTest
SKU: FNab00197
Availability: OnlineOnly

Este producto es parte de AFF - AF4/FMR2 family member

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-AFF4

proveedor

FineTest

reference

FNab00197

Tested Applications

ELISA, WB, IP

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

Key component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins(ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.

Background

The AFF (AF4/FMR2) family member refers to a group of proteins associated with various cellular functions, particularly in the context of gene regulation and transcriptional control. The name "AFF" comes from the fusion partner of MLL (Mixed-Lineage Leukemia) in certain leukemia cases. AFF4 is a transcriptional regulator involved in forming complex transcriptional machinery.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

AF4/FMR2 family, member 4

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IP

observerd MW

150 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:2000; IP: 1:200-1:1000

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

AFF4

alias

AF5Q31,MCEF

uniprot id

https://www.uniprot.org/uniprotkb/Q9UHB7

gene id

https://www.ncbi.nlm.nih.gov/gene/27125

note

This product is for research use only.

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