AFAP1 antibody
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Description
Can cross-link actin filaments into both network and bundle structures(By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | actin filament associated protein 1 (AFAP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 81 kDa, 110 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8N556 |
| Gene ID | 60312 |
| Alias | AFAP,AFAP110,AFAP-110 |
| Background | Antibody anti-AFAP1 |
| Status | RUO |
| Note | Mol. Weight 81 kDa, 110 kDa |
Descripción
Actin Filament Associated Protein 1 (AFAP1), also known as AFAP-110 or AFAP1L1, is a cytoskeletal protein involved in the regulation of actin dynamics and cell motility. AFAP1 is a multidomain protein consisting of several functional domains, including an N-terminal BAR (Bin-Amphiphysin-Rvs) domain, a central proline-rich region, a serine-rich region, and a C-terminal SH3 (Src homology 3) domain. These domains facilitate protein-protein interactions and mediate the binding of AFAP1 to various cytoskeletal and signaling molecules. AFAP1 regulates actin cytoskeleton dynamics by interacting with actin filaments and modulating their organization and stability. It can promote actin polymerization and bundling, as well as cross-linking of actin filaments, thereby influencing cell shape, migration, and adhesion. AFAP1 also plays a role in cell motility and migration by coordinating actin cytoskeleton rearrangements necessary for cell protrusion, adhesion, and movement. It interacts with signaling proteins involved in focal adhesion turnover, cytoskeletal remodeling, and cell contractility
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