anti- ADNP antibody
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Description
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | activity-dependent neuroprotector homeobox |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:5000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 135 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H2P0 |
| Gene ID | 23394 |
| Alias | ADNP, ADNP1, KIAA0784,HVDAS, MRD28 |
| Background | Antibody anti-ADNP |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Activity-dependent neuroprotector homeobox protein (ADNP) is a transcription factor and neuroprotective protein essential for brain development, neurogenesis, and chromatin remodeling through interactions with SWI/SNF chromatin-remodeling complexes It regulates gene expression critical for maintaining neuronal survival, synaptic plasticity, and cognitive processes Mutations or deletions in ADNP cause ADNP syndrome (Helsmoortel-Van der Aa syndrome), a neurodevelopmental disorder marked by intellectual disability, autism spectrum disorder traits, motor dysfunction, and developmental delay ADNP is also linked to neurodegenerative diseases, including Alzheimer’s disease, where it modulates tau phosphorylation, amyloid toxicity, and neuronal resilience Dysregulation of ADNP disrupts cell cycle control, proliferation, and apoptosis pathways, leading to impaired neuronal health and cognitive decline ADNP’s broad involvement in transcriptional regulation, synaptic maintenance, and neuroprotection underscores its essential role in brain function, making it a potential therapeutic target for neurodevelopmental and neurodegenerative diseases
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