ADM2 antibody
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935106861
info@markelab.com
name
ADM2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00173
tested applications
ELISA, IHC
Description
IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adrenomedullin 2 (ADM2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 16 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q7Z4H4 |
| Gene ID | 79924 |
| Alias | AM3 |
| Background | Antibody anti-ADM2 |
| Status | RUO |
| Note | Mol. Weight 16 kDa |
Descripción
Adrenomedullin 2 (ADM2), also known as Intermedin, is a member of the calcitonin gene-related peptide (CGRP) family. This peptide is widely expressed in various tissues, including the brain, cardiovascular system, kidneys, and gastrointestinal tract. ADM2 exerts its biological effects through the calcitonin receptor-like receptor (CLR) in association with receptor activity-modifying proteins (RAMPs). It plays a vital role in maintaining vascular tone, promoting angiogenesis, and regulating fluid and electrolyte balance. ADM2 also has neuroprotective, cardioprotective, and anti-inflammatory properties. Dysregulation of ADM2 signaling has been implicated in conditions such as hypertension, heart failure, and metabolic disorders, highlighting its therapeutic potential in these diseases.
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