ADH4 antibody
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935106861
info@markelab.com
name
ADH4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00164
tested applications
ELISA, WB, IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | alcohol dehydrogenase 4(class II), pi polypeptide (ADH4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 40 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P08319 |
| Gene ID | 127 |
| Alias | ADH-2,HEL-S-4 |
| Background | Antibody anti-ADH4 |
| Status | RUO |
| Note | Mol. Weight 40 kDa |
ADH4 encodes a class II alcohol dehydrogenase primarily expressed in the liver, stomach, and other tissues, where it contributes to the metabolism of various alcohols, including ethanol, retinol, and hydroxysteroids. Unlike class I enzymes, ADH4 has a broader substrate specificity and plays a key role in the detoxification of longer-chain alcohols and other xenobiotics. It is also involved in retinoic acid synthesis, linking it to pathways critical for cellular differentiation and immune responses. Genetic variations in ADH4 can influence enzyme activity and alcohol metabolism rates, impacting susceptibility to alcohol-related liver diseases and cancers. Its ability to process retinol highlights its importance in visual and developmental processes. Dysregulation or polymorphisms in ADH4 have been implicated in increased oxidative stress and tissue damage, particularly in alcohol-related gastrointestinal and liver disorders.
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