Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide (ADH4) Antibody
169€ (20 µl)
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935106861
info@markelab.com
name
Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide (ADH4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx320328
tested applications
ELISA, IHC
Description
ADH4 Antibody is a Rabbit Polyclonal against ADH4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide (ADH4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08319 |
| Gene ID | 127 |
| NCBI Accession | NP_000661.2, NM_000670.4 |
| OMIM | 103740 |
| Alias | ADH-2,HEL-S-4 |
| Background | Antibody anti-ADH4 |
| Status | RUO |
Descripción
ADH4 encodes a class II alcohol dehydrogenase primarily expressed in the liver, stomach, and other tissues, where it contributes to the metabolism of various alcohols, including ethanol, retinol, and hydroxysteroids. Unlike class I enzymes, ADH4 has a broader substrate specificity and plays a key role in the detoxification of longer-chain alcohols and other xenobiotics. It is also involved in retinoic acid synthesis, linking it to pathways critical for cellular differentiation and immune responses. Genetic variations in ADH4 can influence enzyme activity and alcohol metabolism rates, impacting susceptibility to alcohol-related liver diseases and cancers. Its ability to process retinol highlights its importance in visual and developmental processes. Dysregulation or polymorphisms in ADH4 have been implicated in increased oxidative stress and tissue damage, particularly in alcohol-related gastrointestinal and liver disorders.
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