ACTL7A antibody
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | actin-like 7A (ACTL7A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 49 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y615 |
| Gene ID | 10881 |
| Alias | SPGF86 |
| Background | Antibody anti-ACTL7A |
| Status | RUO |
| Note | Mol. Weight 49 kDa |
ACTL7A is a testis-specific actin-like protein predominantly expressed during spermatogenesis. It shares structural homology with canonical actins, including an ATP/ADP-binding site critical for nucleotide interactions. However, ACTL7A does not polymerize into filaments and instead performs unique roles in germ cell cytoskeletal dynamics. It is involved in chromatin remodeling during spermatid maturation, assisting in nuclear shaping and acrosome biogenesis. ACTL7A expression is tightly regulated, and disruptions in its function can lead to male infertility due to defects in sperm morphology and motility.
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ACTL7A antibody
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Actin Like 7A (ACTL7A) Antibody
ACTL7A is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.
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