anti- ACSL1 antibody
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935106861
info@markelab.com
name
anti- ACSL1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00106
tested applications
ELISA, WB, IHC, IP
Description
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acyl-CoA synthetase long-chain family member 1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:200-1:2000; IP: 1:200-1:2000; IF: 1:20-1:200; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 78 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P33121 |
| Gene ID | 2180 |
| Alias | ACS1,LACS,FACL1,FACL2,LACS1,LACS2 |
| Background | Antibody anti-ACSL1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ACSL1 is a long-chain acyl-CoA synthetase that activates long-chain fatty acids, converting them into acyl-CoA derivatives for use in β-oxidation, lipid biosynthesis, and signaling pathways. It is highly expressed in energy-demanding tissues such as the heart, liver, and skeletal muscle, where it supports fatty acid metabolism and energy production during fasting and exercise. ACSL1 is critical for directing fatty acids toward oxidation rather than storage, ensuring metabolic flexibility and maintaining energy balance. Its role extends to regulating lipid signaling molecules, such as eicosanoids, which mediate inflammation and other cellular responses. Dysregulation of ACSL1 has been implicated in metabolic disorders, including insulin resistance, diabetes, and non-alcoholic fatty liver disease, where impaired fatty acid activation contributes to disrupted energy homeostasis and lipid accumulation. ACSL1’s enzymatic activity and tissue-specific expression highlight its central role in coordinating lipid metabolism and systemic energy regulation.
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