ACP5 antibody
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935106861
info@markelab.com
name
ACP5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00100
tested applications
ELISA, IHC, WB, IF
Description
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acid phosphatase 5, tartrate resistant (ACP5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:10-1:100; IF: 1:50-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 37 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P13686 |
| Gene ID | 54 |
| Alias | HPAP,TRACP5a,TRACP5b,TRAP,TRAcP,TrATPase |
| Background | Antibody anti-ACP5 |
| Status | RUO |
| Note | Mol. Weight 37 kDa |
Descripción
Acid phosphatases (ACP) are a group of enzymes that catalyze the hydrolysis of phosphate ester bonds under acidic conditions, resulting in the release of inorganic phosphate from organic molecules. These enzymes are characterized by their ability to function optimally at low pH levels. There are multiple forms of acid phosphatase, often denoted as ACP1, ACP2, ACP3, ACP4, and ACP5. Each isoform may have distinct tissue distribution, substrate specificity, and physiological roles. ACP1. It is found in various tissues and body fluids, including red blood cells, bone, prostate gland, and semen. It is a biomarker for poor prognosis in prostate cancer has been linked to bad clinical prognosis. ACP5 (Tartrate-Resistant Acid Phosphatase - TRAP) is mainly found in bone tissue, particularly in osteoclasts and Involved in bone resorption by osteoclasts, playing a critical role in bone remodeling and calcium homeostasis
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