ACE antibody
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935106861
info@markelab.com
name
ACE antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00080
tested applications
ELISA, WB
Description
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | angiotensin I converting enzyme(peptidyl-dipeptidase A) 1 (ACE) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:5000; IP: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 170 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P12821 |
| Gene ID | 1636 |
| Alias | ACE1,CD143,DCP,DCP1,ICH,MVCD3 |
| Background | Antibody anti-ACE |
| Status | RUO |
| Note | Mol. Weight 170 kDa |
Descripción
Angiotensin converting enzyme (ACE) is a pivotal enzyme in the Renin-Angiotensin-Aldosterone System (RAAS), a key regulator of blood pressure and fluid balance in the body. ACE plays a crucial role in converting angiotensin I to angiotensin II, a potent vasoconstrictor, thereby increasing blood pressure. ACE inhibitors are commonly prescribed medications that block this conversion, leading to vasodilation and reduced blood pressure. Apart from its role in blood pressure regulation, ACE also has functions in the metabolism of other peptides, including bradykinin. Dysregulation of ACE activity is associated with various cardiovascular diseases, such as hypertension, heart failure, and myocardial infarction. ACE inhibitors are widely used in the management of hypertension, heart failure, and certain kidney diseases. ACE gene polymorphisms have been linked to differences in individual responses to ACE inhibitors and susceptibility to cardiovascular diseases. Understanding the role of ACE has led to the development of novel therapeutic strategies targeting the RAAS for the treatment of cardiovascular disorders.
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