anti- ACBD5 antibody
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935106861
info@markelab.com
name
anti- ACBD5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00076
tested applications
ELISA, WB
Description
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium-and long-chain acyl-CoA esters.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acyl-Coenzyme A binding domain containing 5 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 65 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q5T8D3 |
| Gene ID | 91452 |
| Alias | RDLKD |
| Background | Antibody anti-ACBD5 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ACBD5 is a peroxisomal protein that serves a key role in lipid metabolism by transporting very-long-chain fatty acyl-CoA into peroxisomes for beta-oxidation. It acts as a tether between peroxisomes and the endoplasmic reticulum (ER) by interacting with the ER-resident protein VAPB, enabling efficient lipid exchange between these organelles. ACBD5 is essential for maintaining peroxisomal function and lipid homeostasis, with significant implications for energy production and membrane lipid composition. Mutations in ACBD5 are associated with peroxisomal disorders, such as Zellweger spectrum disorders, which are characterized by defects in lipid metabolism. ACBD5 is also being studied for its potential role in modulating inflammation and oxidative stress in metabolic diseases.
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