anti- ACADVL antibody

Name: anti- ACADVL antibody
Brand: FineTest
SKU: FNab00068
Availability: OnlineOnly

Este producto es parte de ACADVL - Very Long-Chain Specific Acyl-CoA Dehydrogenase MitochondriaL

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-ACADVL

proveedor

FineTest

reference

FNab00068

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

Very long-chain acyl-CoA dehydrogenase (VLCAD) is one of four flavoproteins which catalyze the initial step of the mitochondrial b-oxidation spiral. It belongs to the acyl-CoA dehydrogenase family and is a homodimer of a 71-kDa polypeptide. The molecular mass of the nondenatured trypsinized VLCAD is 98 kDa, by gel filtration chromatography, indicating that it is a homodimer of the 48 kDa(tryptic digest) polypeptide(PMID:9461620). Defects in ACADVL are the cause of acyl-CoA dehydrogenase very long chain deficiency (ACADVLD). It has 2 isoforms(70 kDa and 68 kDa ) produced by alternative splicing and a transit peptide.

Background

The ACADVL gene encodes the enzyme acyl-CoA dehydrogenase very long chain, which plays a vital role in the initial step of the mitochondrial fatty acid beta-oxidation pathway. Specifically, it is targeted to the inner mitochondrial membrane and is specific to long-chain and very-long-chain fatty acids. Mutations in this gene are associated with very long-chain acyl-coenzyme A dehydrogenase deficiency, leading to reduced myocardial fatty acid beta-oxidation and cardiomyopathy. Alternative splicing generates multiple transcript variants encoding different isoforms of the enzyme

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

acyl-Coenzyme A dehydrogenase, very long chain

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC

observerd MW

48 kDa,68-73 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

ACADVL

alias

ACAD6,LCACD,VLCAD

uniprot id

https://www.uniprot.org/uniprotkb/P49748

gene id

https://www.ncbi.nlm.nih.gov/gene/37

note

This product is for research use only.

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