anti- ACAD9 antibody
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935106861
info@markelab.com
name
anti- ACAD9 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00062
tested applications
ELISA, WB, IHC
Description
Required for mitochondrial complex I assembly(PubMed:20816094, PubMed:24158852). Has a dehydrogenase activity on palmitoyl-CoA(C16:0) and stearoyl-CoA(C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo(PubMed:20816094, PubMed:24158852). Has little activity on octanoyl-CoA(C8:0), butyryl-CoA(C4:0) or isovaleryl-CoA(5:0).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acyl-Coenzyme A dehydrogenase family, member 9 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 69 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H845 |
| Gene ID | 28976 |
| Alias | MC1DN20,NPD002 |
| Background | Antibody anti-ACAD9 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ACAD9 is a mitochondrial enzyme essential for the β-oxidation of long-chain fatty acids and the assembly of mitochondrial respiratory chain complex I. It functions as a dehydrogenase, catalyzing the first step in the oxidation of long-chain acyl-CoA substrates, generating energy and maintaining lipid homeostasis. ACAD9 is also a critical assembly factor for complex I, facilitating the proper formation and function of this key component of the electron transport chain. Its dual role in fatty acid oxidation and complex I assembly makes ACAD9 indispensable for mitochondrial energy metabolism. Mutations in the ACAD9 gene are associated with complex I deficiency, a severe mitochondrial disorder that can lead to cardiomyopathy, encephalopathy, and metabolic crises. The high expression of ACAD9 in energy-demanding tissues such as the heart, liver, and brain reflects its importance in maintaining mitochondrial function and energy production, positioning it as a vital enzyme in cellular metabolism.
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