anti- ABHD6 antibody
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935106861
info@markelab.com
name
anti- ABHD6 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00051
tested applications
ELISA, WB
Description
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol(PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | abhydrolase domain containing 6 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:200-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 38 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9BV23 |
| Gene ID | 57406 |
| Alias | ABHD6, Monoacylglycerol lipase ABHD6 |
| Background | Antibody anti-ABHD6 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ABHD6 is a serine hydrolase that modulates lipid signaling by hydrolyzing monoacylglycerols, including 2-arachidonoylglycerol (2-AG), a key endocannabinoid. Through its regulation of 2-AG levels, ABHD6 influences cannabinoid receptor signaling, which affects processes such as pain perception, appetite, and inflammation. ABHD6 is expressed in multiple tissues, including the brain, pancreas, and immune cells, where it plays roles in synaptic activity, glucose homeostasis, and immune responses. It has also been implicated in neuroinflammation and metabolic disorders, with potential links to diseases such as Alzheimer’s and diabetes. Structurally, ABHD6’s hydrolase domain is specialized for monoacylglycerol hydrolysis, making it a key regulator of endocannabinoid tone. As a critical enzyme in lipid signaling and metabolism, ABHD6 is a promising therapeutic target for treating neurodegenerative diseases, metabolic conditions, and chronic pain.
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