anti- ABHD5 antibody
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Description
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis(PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2(PubMed:16679289). Involved in keratinocyte differentiation(PubMed:18832586). Regulates lipid droplet fusion(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | abhydrolase domain containing 5 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 39 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8WTS1 |
| Gene ID | 51099 |
| Alias | CGI58,IECN2,NCIE2 |
| Background | Antibody anti-ABHD5 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ABHD5, also known as CGI-58, is a critical coactivator of adipose triglyceride lipase (ATGL), a key enzyme in lipolysis. It promotes the hydrolysis of triglycerides into glycerol and free fatty acids, thereby regulating lipid storage and energy metabolism. ABHD5 is highly expressed in adipose tissue, liver, and muscles, where it plays an essential role in lipid mobilization and energy balance. Mutations in the ABHD5 gene are associated with Chanarin-Dorfman syndrome, a rare lipid storage disorder characterized by excessive lipid accumulation in various tissues. Beyond lipolysis, ABHD5 influences lipid signaling pathways and cellular lipid composition, affecting processes such as inflammation and metabolic homeostasis. Dysregulation of ABHD5 activity can contribute to obesity, insulin resistance, and other metabolic syndromes, highlighting its critical role in energy regulation and lipid metabolism.
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Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis(PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2(PubMed:16679289). Involved in keratinocyte differentiation(PubMed:18832586). Regulates lipid droplet fusion(By similarity).
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