anti- AATF antibody

Name: anti- AATF antibody
Brand: FineTest
SKU: FNab00025
Availability: OnlineOnly

Este producto es parte de AATF - Apoptosis Antagonizing Transcription Factor

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-AATF

proveedor

FineTest

reference

FNab00025

Tested Applications

ELISA, WB, IF

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Background

AATF (Apoptosis Antagonizing Transcription Factor), also known as Che-1, is a transcription factor involved in various cellular processes, including the regulation of apoptosis, cell cycle progression, and DNA damage response. It acts as a survival factor by inhibiting apoptotic pathways and promoting cell proliferation and survival.It also interacts directly with nuclear hormone receptors to enhance their transactivation. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

apoptosis antagonizing transcription factor

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IF

observerd MW

63 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:2000; IF: 1:10-1:100

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

AATF

alias

DED,BFR2,CHE1,CHE-2

uniprot id

https://www.uniprot.org/uniprotkb/Q9NY61

gene id

https://www.ncbi.nlm.nih.gov/gene/26574

note

This product is for research use only.

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