Annexin V (ANXA5) Antibody
292.5€ (80 µl)
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Name
Annexin V (ANXA5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx032879
Tested Applications
ELISA, WB, IHC
Description
Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Annexin V (ANXA5) Immunogen: KLH-conjugated synthetic peptide between 262-291 amino acids from the C-terminal region of human Annexin V. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 35.9 kDa |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08758, P14668, P48036 |
| Gene ID | 308 |
| Alias | ANXA5,ANX5,ENX2,PP4 |
| Background | Antibody anti-ANXA5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ANXA5 is a well-known calcium- and phospholipid-binding protein involved in apoptosis, membrane repair, and anti-inflammatory processes. It binds to phosphatidylserine (PS), a phospholipid exposed on the outer leaflet of apoptotic cells, making ANXA5 a widely used marker for apoptosis detection. ANXA5 regulates coagulation and fibrinolysis by preventing the assembly of coagulation complexes on cell membranes, contributing to antithrombotic activity. It is expressed in various tissues, including the placenta, where it plays roles in trophoblast function and pregnancy maintenance. Dysregulation of ANXA5 has been associated with autoimmune diseases, recurrent pregnancy loss, and cancers. Its apoptotic and anticoagulant properties make it a key protein in cellular homeostasis and disease pathology.
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