Annexin V (ANXA5) Antibody
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935106861
info@markelab.com
Precio
208€ (20 µl)
Antibody anti-ANXA5
proveedor
Abbexareference
abx001443Tested Applications
ELISA, WB, IF/ICCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
Annexin V Antibody is a Rabbit Polyclonal antibody against Annexin V. The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
Background
ANXA5 is a well-known calcium- and phospholipid-binding protein involved in apoptosis, membrane repair, and anti-inflammatory processes. It binds to phosphatidylserine (PS), a phospholipid exposed on the outer leaflet of apoptotic cells, making ANXA5 a widely used marker for apoptosis detection. ANXA5 regulates coagulation and fibrinolysis by preventing the assembly of coagulation complexes on cell membranes, contributing to antithrombotic activity. It is expressed in various tissues, including the placenta, where it plays roles in trophoblast function and pregnancy maintenance. Dysregulation of ANXA5 has been associated with autoimmune diseases, recurrent pregnancy loss, and cancers. Its apoptotic and anticoagulant properties make it a key protein in cellular homeostasis and disease pathology.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Annexin V (ANXA5)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IF/ICC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ANXA5
dry ice
No
availability
Shipped within 5-10 working days.
alias
ANXA5,ANX5,ENX2,PP4
uniprot id
NCBI accession
NP_001145.1
note
Concentration: > 0.2 mg/ml -
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