Annexin A11 (ANXA11) Protein

Background

ANXA11 is a multifunctional protein involved in calcium signaling, RNA transport, and cell cycle regulation. It plays an important role in nuclear-cytoplasmic transport by binding RNA and contributing to the assembly of RNA granules. ANXA11 is also critical for cytokinesis, ensuring proper cell division by localizing to the midbody during the final stages of mitosis. Mutations in ANXA11 have been linked to amyotrophic lateral sclerosis (ALS), where defects in RNA transport and protein aggregation contribute to neurodegeneration. Dysregulation of ANXA11 has also been implicated in autoimmune diseases and cancer progression. Its diverse roles in RNA metabolism, calcium signaling, and cytokinesis make ANXA11 essential for cellular homeostasis and division.