Annexin A11 (ANXA11) Antibody
169€ (20 µl)
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935106861
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name
Annexin A11 (ANXA11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx321681
tested applications
ELISA, WB, IHC, IF/ICC
Description
ANXA11 Antibody is a Rabbit Polyclonal against ANXA11.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Annexin A11 (ANXA11) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P50995 |
| Gene ID | 311 |
| NCBI Accession | NP_001148.1, NM_001157.2 |
| OMIM | 602572 |
| Alias | ANXA11,ANX11,Annexin XI |
| Background | Antibody anti-ANXA11 |
| Status | RUO |
Descripción
ANXA11 is a multifunctional protein involved in calcium signaling, RNA transport, and cell cycle regulation. It plays an important role in nuclear-cytoplasmic transport by binding RNA and contributing to the assembly of RNA granules. ANXA11 is also critical for cytokinesis, ensuring proper cell division by localizing to the midbody during the final stages of mitosis. Mutations in ANXA11 have been linked to amyotrophic lateral sclerosis (ALS), where defects in RNA transport and protein aggregation contribute to neurodegeneration. Dysregulation of ANXA11 has also been implicated in autoimmune diseases and cancer progression. Its diverse roles in RNA metabolism, calcium signaling, and cytokinesis make ANXA11 essential for cellular homeostasis and division.
