Ankyrin Repeat Domain 2 (ANKRD2) Antibody
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Description
ANKRD2 Antibody is a Rabbit Polyclonal antibody against ANKRD2. This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ankyrin Repeat Domain 2 (ANKRD2) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9GZV1 |
| Gene ID | 26287 |
| NCBI Accession | NP_001123453.1 |
| Alias | ANKRD2,ARPP |
| Background | Antibody anti-ANKRD2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ANKRD2, also known as Arpp (ankyrin repeat protein with PEST domain), is a member of the muscle ankyrin repeat protein (MARP) family. It is predominantly expressed in skeletal and cardiac muscle, where it localizes to the nucleus and the sarcomere, linking mechanical stress signals to gene expression. ANKRD2 functions as a stress-response protein that regulates transcription in response to mechanical stretch, injury, or oxidative stress. It interacts with key sarcomeric proteins such as titin and myopalladin and participates in processes like muscle differentiation, maintenance, and repair. ANKRD2 is upregulated during muscle damage and various cardiomyopathies, suggesting a role in pathological remodeling. Dysregulation of ANKRD2 has been associated with muscular dystrophies, hypertrophy, and heart failure, where it acts as a molecular sensor that influences cellular survival pathways. Its role in muscle homeostasis highlights its importance in maintaining mechanical stability and cellular adaptation during stress.
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