Ankyrin Repeat Domain 11 (ANKRD11) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Ankyrin Repeat Domain 11 (ANKRD11) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx315451
Description
ANKRD11 Antibody (FITC) is a Rabbit Polyclonal against ANKRD11 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ankyrin Repeat Domain 11 (ANKRD11) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6UB99 |
| Gene ID | 29123 |
| OMIM | 148050 |
| Alias | ANCO-1,ANCO1,LZ16,T13 |
| Background | Antibody anti-ANKRD11 |
| Status | RUO |
Descripción
ANKRD11 is a multifunctional protein that interacts with histone deacetylases (HDACs) to regulate histone acetylation, thereby influencing chromatin structure and gene expression. It plays a critical role in neural development, acting as a co-regulator of transcription factors that control neuronal differentiation and synaptic function. Mutations in ANKRD11 are linked to KBG syndrome, a rare neurodevelopmental disorder characterized by intellectual disability, distinct craniofacial features, and skeletal anomalies. ANKRD11 has also been implicated in autism spectrum disorders and cancer progression, where it contributes to altered cell growth, differentiation, and survival. Its role in epigenetic regulation and transcriptional modulation makes ANKRD11 essential for proper cellular function, particularly in the nervous system and during embryonic development.
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