Ankyrin B (ANKB) Antibody

Este producto es parte de ANK - Ankyrin
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585€ (100 µg)

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935106861
info@markelab.com
name
Ankyrin B (ANKB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx445011
tested applications
WB, IHC, IF/ICC

Description

Ankyrin B Antibody is a Mouse Monoclonal antibody against Ankyrin B.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Ankyrin B (ANKB)
Host
Mouse
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1/1000, IHC: 1/200, IF/ICC: 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purification
Purified by Protein G.
Size 1
100 µg
Tested Applications
WB, IHC, IF/ICC
Buffer
PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q01484
Gene ID
287
NCBI Accession
NP_001120965.1
Alias
ANK2,ANKB,Ankyrin-B,Brain ankyrin
Background
Antibody anti-ANK2
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

ANK2, also known as ankyrin-B, is a ubiquitously expressed cytoskeletal adaptor protein that plays essential roles in the organization of membrane domains, ion channel localization, and cellular signaling. ANK2 is highly expressed in cardiac muscle and neurons, where it anchors proteins such as ion channels, transporters, and signaling molecules to the spectrin-actin cytoskeleton, ensuring the proper functioning of cellular compartments. In the heart, ANK2 regulates the localization of critical ion channels such as the Na+/K+ ATPase, Na+/Ca2+ exchanger, and voltage-gated sodium channels, making it essential for maintaining cardiac electrophysiology and calcium homeostasis. Mutations in ANK2 are associated with ankyrin-B syndrome, a disorder that includes cardiac arrhythmias, such as long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT). In neurons, ANK2 is involved in axonal organization, synaptic transmission, and neurodevelopment. Dysregulation of ANK2 has been linked to neurological disorders and cardiac pathologies, underscoring its importance in maintaining ion channel function, cellular organization, and physiological homeostasis.

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