Angiopoietin-Related Protein 7 (ANGPTL7) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Angiopoietin-Related Protein 7 (ANGPTL7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036103
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ANGPTL7 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiopoietin-Related Protein 7 (ANGPTL7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AngX,CDT6 |
| Background | Antibody anti-ANGPTL7 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ANGPTL7 is a secreted glycoprotein and a member of the angiopoietin-like (ANGPTL) protein family that regulates extracellular matrix (ECM) remodeling, angiogenesis, and ocular physiology. ANGPTL7 is highly expressed in the cornea and aqueous humor, where it plays a critical role in maintaining intraocular pressure and corneal transparency by modulating ECM composition and fluid outflow. Elevated levels of ANGPTL7 have been linked to primary open-angle glaucoma (POAG), a condition characterized by increased intraocular pressure and optic nerve damage. ANGPTL7 is also involved in tissue homeostasis and fibrosis through its regulation of collagen deposition and matrix degradation. Beyond its ocular functions, ANGPTL7 expression is upregulated under inflammatory conditions, suggesting a role in immune modulation and wound healing. Dysregulation of ANGPTL7 has been observed in certain cancers, where it may contribute to tumor progression by remodeling the tumor microenvironment. Its importance in ocular health and ECM regulation highlights ANGPTL7 as a potential therapeutic target for glaucoma and fibrotic diseases.
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