Angiopoietin-2 (ANGPT2) Antibody
299€ (50 µl)
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Name
Angiopoietin-2 (ANGPT2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402085
Tested Applications
ELISA, WB, IHC
Description
Angiopoietin-2 (ANGPT2) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human ANGPT2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Angiopoietin-2 (ANGPT2) Immunogen: A synthesized peptide derived from human Angiopoietin 2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15123 |
| Gene ID | 285 |
| OMIM | 601922 |
| Alias | AGPT2,ANG2,LMPHM10 |
| Background | Antibody anti-ANGPT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ANGPT2 is a secreted protein that functions as a context-dependent antagonist or agonist of the Tie2 receptor, depending on cellular and environmental conditions. ANGPT2 disrupts ANGPT1-Tie2 signaling under inflammatory or angiogenic conditions, leading to increased vascular permeability, endothelial activation, and vessel destabilization. ANGPT2 is expressed primarily in the vasculature, where it facilitates vascular remodeling during angiogenesis, inflammation, and tissue repair. It plays a key role in pathological angiogenesis observed in cancer, where it promotes the formation of abnormal, leaky blood vessels that support tumor growth and metastasis. ANGPT2 also acts as a regulator of inflammatory responses by enhancing endothelial activation and leukocyte recruitment. Elevated ANGPT2 levels are associated with diseases such as sepsis, diabetic vascular complications, and cardiovascular diseases, where excessive vascular permeability and endothelial dysfunction occur. ANGPT2 serves as a biomarker for vascular injury and a potential therapeutic target for stabilizing blood vessels in pathological conditions.
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