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Angiopoietin-2 (ANGPT2) Antibody
proveedor
Abbexareference
abx000833Tested Applications
WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
ANGPT2 Antibody is a Rabbit Polyclonal antibody against ANGPT2. The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
Background
Angiogenin 2 (ANG2), also known as Angiopoietin 2 (ANGPT2), plays a role in facilitating ribonuclease activity and is involved in various cellular processes, including cardiac muscle cell development, responses to glucose stimulus, and the positive regulation of protein phosphorylation. It exhibits a strong binding affinity to placental ribonuclease inhibitor but possesses very low ribonuclease activity itself. ANG2 is notably potent in promoting angiogenesis, contributing to the vascularization of both normal and malignant tissues. One of its significant functions is the inhibition of protein synthesis through the specific hydrolysis of cellular transfer RNAs (tRNAs). It is recognized by several aliases, including ANG2, Angiopoietin 2, ANG-2, ANGPT2, and AGPT2.
Background
La Angiogenina 2 (ANG2), también conocida como angiopoyetina 2 (ANGPT2), desempeña un papel en la facilitación de la actividad de la ribonucleasa y participa en diversos procesos celulares, incluido el desarrollo de las células del músculo cardíaco, las respuestas al estímulo de la glucosa y la regulación positiva de la fosforilación de proteínas. Muestra una fuerte afinidad de unión al inhibidor de la ribonucleasa placentaria, pero posee una actividad de ribonucleasa muy baja. ANG2 es notablemente potente para promover la angiogénesis, contribuyendo a la vascularización de tejidos tanto normales como malignos. Una de sus funciones importantes es la inhibición de la síntesis de proteínas mediante la hidrólisis específica de los ARN de transferencia celular (ARNt). Se reconoce por varios alias, incluidos ANG2, Angiopoyetin 2, ANG-2, ANGPT2 y AGPT2.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Angiopoietin-2 (ANGPT2)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IF/ICC
purification
Purified by affinity chromatography.
buffer
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
size 1
20 µl
size 2
50 µl
size 3
100 µl
size 4
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ANGPT2
dry ice
No
availability
Shipped within 5-10 working days.
alias
AGPT2,ANG2,LMPHM10
uniprot id
NCBI accession
NP_001138.1
note
This product is for research use only.
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