Androgen Receptor Protein (AR) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Androgen Receptor Protein (AR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025510
tested applications
ELISA, WB
Description
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Androgen Receptor Protein (AR) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgA |
| Purification | Purified Mouse Monoclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10275 |
| Alias | KD,AIS,AR8,TFM,DHTR,SBMA,HYSP1,NR3C4,SMAX1,HUMARA,Dihydrotestosterone receptor,Nuclear receptor subfamily 3 group C member 4 |
| Background | Antibody anti-AR |
| Status | RUO |
Descripción
Androgen receptor (AR) is a nuclear receptor that mediates the effects of androgens, the male sex hormones, by regulating gene expression AR plays a critical role in the development and maintenance of male sexual characteristics, as well as in the regulation of muscle mass, bone density, and red blood cell production It functions by binding to androgen hormones, such as testosterone, and translocating into the nucleus, where it interacts with DNA to regulate the transcription of target genes involved in cell growth, differentiation, and metabolism AR is essential for normal male development, including the formation of the male reproductive organs and secondary sexual characteristics During adulthood, AR helps maintain prostate function, muscle mass, and bone density Mutations in the AR gene can lead to a variety of disorders, including androgen insensitivity syndrome, prostate cancer, and certain types of hair loss, where abnormal AR signaling contributes to disease development AR is also a therapeutic target for androgen-related diseases, including prostate cancer, where therapies aim to block or modulate AR activity
Related Products
Human AR (Androgen receptor) ELISA Kit
Ver Producto
Mouse AR (Androgen receptor) ELISA Kit
Ver Producto