Anaphase Promoting Complex Subunit 5 (ANAPC5) Antibody (HRP)
169€ (20 µg)
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Name
Anaphase Promoting Complex Subunit 5 (ANAPC5) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx107969
Tested Applications
ELISA
Description
ANAPC5 Antibody (HRP) is a Rabbit Polyclonal antibody against ANAPC5 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Anaphase Promoting Complex Subunit 5 (ANAPC5) Immunogen: Recombinant human Anaphase-promoting complex subunit 5 protein (2-232AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UJX4 |
| Gene ID | 51433 |
| NCBI Accession | NP_001131031.1, NM_001137559.1 |
| OMIM | 606948 |
| Alias | ANAPC5,APC5,Cyclosome subunit 5 |
| Background | Antibody anti-ANAPC5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ANAPC5 is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) that contributes to the stability and assembly of the complex. It interacts with other subunits to form the platform necessary for substrate recognition and ubiquitination. ANAPC5 facilitates the recruitment of co-activators such as CDC20 and CDH1, which are required for targeting specific proteins for proteolysis during the cell cycle. By promoting the degradation of regulators like securin and cyclin B, ANAPC5 ensures proper chromosome segregation and mitotic exit. Loss or mutation of ANAPC5 impairs APC/C function, leading to cell cycle arrest, chromosomal instability, and an increased risk of cancer. ANAPC5’s role in the structural integrity of APC/C highlights its importance in maintaining genomic stability and normal cell division. Dysregulation of ANAPC5 is a hallmark of mitotic errors often observed in tumorigenesis.
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