Anaphase Promoting Complex Subunit 5 (ANAPC5) Antibody
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Description
ANAPC5 Antibody is a Rabbit Polyclonal antibody against ANAPC5.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase Promoting Complex Subunit 5 (ANAPC5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UJX4 |
| Gene ID | 51433 |
| NCBI Accession | NP_001131031.1, NM_001137559.1, NP_001317418.1, NM_001330489.1, NP_057321.2, NM_016237.4 |
| OMIM | 606948 |
| Alias | ANAPC5,APC5,Cyclosome subunit 5 |
| Background | Antibody anti-ANAPC5 |
| Status | RUO |
Descripción
ANAPC5 is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) that contributes to the stability and assembly of the complex. It interacts with other subunits to form the platform necessary for substrate recognition and ubiquitination. ANAPC5 facilitates the recruitment of co-activators such as CDC20 and CDH1, which are required for targeting specific proteins for proteolysis during the cell cycle. By promoting the degradation of regulators like securin and cyclin B, ANAPC5 ensures proper chromosome segregation and mitotic exit. Loss or mutation of ANAPC5 impairs APC/C function, leading to cell cycle arrest, chromosomal instability, and an increased risk of cancer. ANAPC5’s role in the structural integrity of APC/C highlights its importance in maintaining genomic stability and normal cell division. Dysregulation of ANAPC5 is a hallmark of mitotic errors often observed in tumorigenesis.
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