Anaphase Promoting Complex Subunit 5 (ANAPC5) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
ANAPC5 Antibody is a Rabbit Polyclonal against ANAPC5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase Promoting Complex Subunit 5 (ANAPC5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UJX4 |
| Gene ID | 51433 |
| Alias | ANAPC5,APC5,Cyclosome subunit 5 |
| Background | Antibody anti-ANAPC5 |
| Status | RUO |
Descripción
ANAPC5 is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) that contributes to the stability and assembly of the complex. It interacts with other subunits to form the platform necessary for substrate recognition and ubiquitination. ANAPC5 facilitates the recruitment of co-activators such as CDC20 and CDH1, which are required for targeting specific proteins for proteolysis during the cell cycle. By promoting the degradation of regulators like securin and cyclin B, ANAPC5 ensures proper chromosome segregation and mitotic exit. Loss or mutation of ANAPC5 impairs APC/C function, leading to cell cycle arrest, chromosomal instability, and an increased risk of cancer. ANAPC5’s role in the structural integrity of APC/C highlights its importance in maintaining genomic stability and normal cell division. Dysregulation of ANAPC5 is a hallmark of mitotic errors often observed in tumorigenesis.
Related Products
ANAPC5 antibody
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
Ver Producto
Anaphase Promoting Complex Subunit 5 (ANAPC5) Antibody
ANAPC5 Antibody is a Rabbit Polyclonal Antibody against ANAPC5.
Ver Producto
Anaphase Promoting Complex Subunit 5 (ANAPC5) Antibody
Rabbit polyclonal antibody against ANAPC5 protein. Immunogen region is Internal.
Ver Producto