Amyloid Beta Precursor Protein Binding Protein A3 (APBA3) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Amyloid Beta Precursor Protein Binding Protein A3 (APBA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030683
tested applications
ELISA, WB
Description
The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Amyloid Beta Precursor Protein Binding Protein A3 (APBA3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O96018 |
| Alias | APBA3, MGC:15815, X11L2, mint3, amyloid beta precursor protein binding family A member 3 |
| Background | Antibody anti-APBA3 |
| Status | RUO |
Descripción
APBA3, another member of the X11 protein family, is involved in the binding and regulation of the amyloid-beta precursor protein (APP). Unlike other members, APBA3 is highly expressed in a variety of tissues, including brain, heart, and liver, where it regulates both APP trafficking and protein stability. It binds APP through its phosphotyrosine-binding (PTB) domain and modulates its intracellular transport, preventing abnormal amyloid-beta production. APBA3 has additional roles beyond APP regulation, including its participation in vesicular transport, endocytosis, and regulation of apoptotic pathways. The protein is also implicated in immune regulation, where it interacts with components of the Toll-like receptor signaling pathway, suggesting a role in inflammatory responses. Dysregulation of APBA3 expression can contribute to amyloid plaque formation, mitochondrial dysfunction, and oxidative stress, particularly in neurodegenerative disorders such as Alzheimer’s disease. Furthermore, its involvement in cellular apoptosis suggests that APBA3 may also play a role in cancer progression and metabolic disorders. Understanding its mechanisms in APP metabolism and cellular signaling offers promising therapeutic opportunities to target neurodegenerative conditions and inflammatory processes.
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