Aminopeptidase N (ANPEP) Antibody
292.5€ (80 µl)
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name
Aminopeptidase N (ANPEP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025435
tested applications
ELISA, WB
Description
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aminopeptidase N (ANPEP) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15144 |
| Gene ID | 290 |
| OMIM | 151530 |
| Alias | APN,AP-M,AP-N,CD13,LAP1,P150,PEPN,Hapn,GP150,Aminopeptidase N,Alanyl aminopeptidase,Microsomal aminopeptidase,Myeloid plasma membrane glycoprotein |
| Background | Antibody anti-ANPEP |
| Status | RUO |
Descripción
ANPEP, also known as alanyl aminopeptidase or aminopeptidase N (APN), is a key membrane-bound enzyme that plays a significant role in the hydrolysis of peptides. The gene ANPEP encodes this enzyme, which is expressed predominantly on the surface of epithelial cells in the small intestine, kidney, and other tissues, and also in certain immune cells such as monocytes, macrophages, and granulocytes. ANPEP is classified as a zinc metalloprotease, which means that its catalytic activity depends on a zinc ion in its active site. In the small intestine, ANPEP facilitates the final stages of protein digestion by cleaving neutral amino acids from the N-terminus of oligopeptides. Beyond its digestive role, ANPEP also participates in various physiological processes, including antigen processing, angiogenesis, immune response regulation, and the inflammatory response
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