Aminomethyltransferase, Mitochondrial (AMT) Antibody
195€ (20 µl)
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935106861
info@markelab.com
name
Aminomethyltransferase, Mitochondrial (AMT) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx135846
tested applications
ELISA, WB, IF/ICC
Description
AMT Antibody is a Rabbit Polyclonal against AMT.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aminomethyltransferase, Mitochondrial (AMT) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48728 |
| Gene ID | 275 |
| NCBI Accession | NP_001158184.1 |
| Alias | AMT,GCST |
| Background | Antibody anti-AMT |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
AMT or Aminomethyltransferase also known as Glycine N-Methyltransferase (GNMT), plays a role in the metabolism of amino acids, particularly glycine (Glycine cleavage system,GCS). AMT/GNMT is an enzyme found in the mitochondria of cells, particularly in the liver. Its primary function is to catalyze the conversion of glycine to sarcosine (N-methylglycine) in the presence of S-adenosylmethionine (SAM). This reaction is part of the methionine cycle, which is involved in the metabolism of methionine, an essential amino acid. The methionine cycle is important for various metabolic processes, including the synthesis of proteins, DNA, and other molecules. In the methionine cycle, methionine is converted to SAM, which is a universal methyl donor in numerous biological reactions. AMT/GNMT helps regulate the levels of SAM by converting glycine to sarcosine, thereby indirectly affecting methionine metabolism. SAM, produced in the methionine cycle, is a key methyl donor for various methylation reactions which are essential for the regulation of gene expression, metabolism of neurotransmitters, and other critical processes
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